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Este enfoque mantiene niveles de pptido ms consistentes durante el da y a menudo se recomienda para lesiones activas u objetivos teraputicos significativos

In the loading dose group, daily intranasal cobalamin administration led to a rapid rise in total serum vitamin B12 levels, increasing from a median of 230 to 1090 pmol/L within two weeks

In female mice, the incidences of pituitary gland adenomas and mammary gland adenocarcinomas and adenoacanthomas were increased at dietary doses of 3 to 30 mg/kg/day (0.1 to 0.9 times human exposure at MRHD based on AUC and 0.5 to 5 times the MRHD based on mg/m2)

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